Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area

نویسندگان

  • Larisa Kuznetsova Department of Clinical Immunology and Allergology, National Medical Academy for Post Graduate Education
  • Mohammad Reza Sheikh Sajjadieh Department of Clinical Immunology and Allergology, National Medical Academy for Post Graduate Education | Ukrainian Specialized Dispensaries of Radiation Defend Population, Kiev, Ukraine
  • vadim Bojenko Ukrainian Specialized Dispensaries of Radiation Defend Population, Kiev, Ukraine
چکیده مقاله:

Background: The effect of low dose radiation on immune system is shown. Ionizing radiation can affect cytokine production and polarization of T helper cells. Objective: The current study focused on ionizing radiation in Ukrainian children residing in a contaminated area with clinical irritable bowel syndrome. Method: Our study included 75 rural children population aged 4-18 yrs, who lived in a contaminated area exposed to natural environmental radiation with clinical irritable bowel syndrome (categorized in three groups) and 20 rural children participants aged 5-15 yrs who were living in areas with similar levels of radioactive contamination without clinical irritable bowel syndrome as control group. Internal radiation activity was measured by gamma-ray spectrometry. Serum levels of IL-4 and IFN-γ were measured by enzyme linked immunosorbent assay. Results: A trend towards increased levels of IL-4 was observed in children with clinical irritable bowel syndrome. In these children, IFN-γ levels were lower than that of the control group. Conclusion: The IBS symptoms in Ukrainian children residing in a contaminated area may have stemmed from Th1 to Th2 immune deviation and differential expression of IL-4 and IFN-γ.

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cytokine status in ukrainian children with irritable bowel syndrome residing in a radioactive contaminated area

background: the effect of low dose radiation on immune system is shown. ionizing radiation can affect cytokine production and polarization of t helper cells. objective: the current study focused on ionizing radiation in ukrainian children residing in a contaminated area with clinical irritable bowel syndrome. method: our study included 75 rural children population aged 4-18 yrs, who lived in a ...

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عنوان ژورنال

دوره 9  شماره 4

صفحات  248- 253

تاریخ انتشار 2012-12-01

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